Abstract Background In 2013, the Declaration of Helsinki changed to mandate that all
research studies involving human subjects, rather than just clinical trials alone, must have a
protocol registered in a publicly accessible database prior to the enrolment of the first
patient. The objective of this work was to assess the number of research studies involving
human participants published in leading journals of plastic surgery that had either published
a protocol or registered a protocol with a publicly accessible database. Materials and …

Background: In 2013, the Declaration of Helsinki mandated that every research study
involving human subjects must have its protocol registered in a publicly accessible database
prior to the enrolment of the first patient. This systematic review assessed the number of
studies published in leading journals of plastic surgery that had either published or
registered a protocol with a publicly accessible database. Material and methods: All
research articles involving human participants published in Plastic and Reconstructive …